Clay Siegall develops ingenious method for producing monoclonal antibodies

In the early 1990s, a man named Clay Siegall devised an idea that would allow for the delivery of highly lethal cytotoxins to the site of malignant tissues. This was an extremely important development due to the fact that it potentially would eliminate completely the side effects associated with chemotherapy, which were oftentimes responsible for some of the most severe side effects of any drug known to man, including death.

While working as a senior researcher at Bristol-Myers Squibb, Dr. Siegall and his team began devising a way to use human antibodies to deliver chemotherapeutic agents directly to malignant tissues, bypassing the need for systemic release of highly lethal poisons into the patient’s system. The means by which Dr. Siegall at his team synthesized these antibodies had never been attempted before.

The crucial insight came from the fact that mammals will produce antibodies to any foreign tissue introduced into their body. Using this idea, Dr. Siegall was able to inject mice with malignant tissues of various types of cancer, causing an immediate reaction in the mouse’s body which produced large numbers of antibodies. While these antibodies were rarely ever effective in treating highly malignant cancers, they were almost invariably effective at creating a molecular key that would allow the antibody itself to seek out and then latch onto the malignant tissue. Dr. Clay Siegall hypothesized that if he could use these antibodies as a vehicle to deliver a cytotoxin, he could completely avoid the systemic release of large amounts of poison into a patient’s bloodstream.

Dr. Siegall and his team then created methods by which they could synthetically alter these antibodies by ever-so-slight means, creating thousands of antibodies they could test for the minimal allergic response in human subjects. By this means, they were able to create hypoallergenic antibodies that served as vehicles to which lethal cytotoxins could be bound, directly delivering the payload to the site of the malignancies.

Today, these so-called antibody drug conjugates are among the most innovative and promising new drugs in the arsenal that oncologists have at their disposal in the fight against cancer.

 

Why Matthew Autterson is an Avid Business Leader

Matthew Autterson prides himself on being highly experienced in matters regarding financial services, especially because he has been in the industry for about 25 years. In the course of his career, he served one of the country’s largest state chartered financial institutions in the capacity of president. Currently, Matthew Autterson holds several positions such as chief executive officer, board member and president of CNS Bioscience, Inc. Since being founded by Scott Falci in 2013, the company operates as a clinical-stage drug development entity that targets neurological pain.

Aside from being an experienced business personality, Matthew Autterson is well-educated. He holds a BA in Finance degree from Michigan Stet University where he graduated in 1980. Later, he joined the Graduate Tax Program at the University of Denver.

Career Journey of Matthew Autterson

Matthew Autterson dived into the finance industry by joining First Trust Corporation before leaving the company in 1982. In turn, he joined a small team that formed a new Colorado state chartered trust entity that would operate as a subsidiary of Integrated Resources, Inc., a financial services enterprise located in New York. Things continued to take an upward turn for Matthew Autterson, as he assumed the presidency role at Resources Trust Company in 1986.

Broad Inc. bought all assets held by Integrated Resources, Inc, along with Resources Trust Company to become SunAmerica Inc. Later in 1988, AIG acquired the company for a whopping $18 billion. In turn, Fiserv acquired Resources Trust Company from AIG in May 2001.Before concluding the acquisition, Resources Trust Company topped as one of the country’s largest state-chartered as well as FDIC-insured depository trust institutions. At the time, it delivered both custodial and depository services to an excess of 200, 000 customers who had been introduced to the company through its 15,000 plus independent financial advisors. Aside from having about 700 employees, Resources Trust Company had more than $1.0 billion in deposits and $20 billion custodial assets.

Philanthropic Interests and Membership

Matthew Autterson holds a membership seat on Falci Adaptive Biosystems’ board of directors. Since the organization is a business leader in Colorado, it represents most of Autterson’s philanthropic interests citing his many years of leadership roles on the boards of various organizations. Some of these institutions include the Webb-Waring Foundation, Denver Zoo, Denver Hospice, and the Denver Zoological Foundation. Furthermore, Matthew Autterson is a former member of various organizations including the World Presidents Organization and Young Presidents Organization.

Lessons In Education From Rocketship Education

Rocketship Education is now ten years old. The first Rocketship school was opened a decade ago in a California church. They learnt a lot during these ten years, and following are some of the lessons that they learned.

The first is that personalized education starts from home. Rocketship Education is known for using technology and other methods to provide personalized education to every student. They also make a visit to the student’s home once a year. This way, they can understand the family dynamics and provide an education that is truly personalized.

The second is that to change the system, they need to create demand. That is why Rocketship Education is still only until the fifth grade and not beyond that. If they would expand it until the twelfth grade, there would not be enough demand that would help them get the support and resources they need.

Another is that they need to honor the power of the parents. Rocketship Education has a parent leadership program, which is designed to help parents have a voice and lobby for the needs of their kids. Therefore, even though Rocketship Education schools continue only until middle school, the parents have been able to band together and lobby for a better system in the schools where their kids go after that.

Another is that they value teacher diversity. They believe in student diversity, of course, but they realize that teacher diversity, having teachers of many different backgrounds, is a great aspect of the success of students.

Another is that actions speak louder than words. The people who launched Rocketship Education didn’t have children when they started it, but now that they have children, they send them to a Rocketship school. This shows that they believe in what they created and in the models of education that they use for other students.

Rocketship Education is a unique school network that empowers parents and students. Parents take part in the interviews of potential teachers, which is certainly an innovative idea. In addition, they are known to use technology to provide a unique and personalized education to all of their students.

 

Classdojo Giving Educationists a Chance to Create Implausible Classroom Settings

A blackboard and a piece of chalk are no longer needed in today’s classroom settings. From kindergarten all the way to graduate programs, classrooms are becoming heavily reliant on technology. Unlike in the previous years that cell phones and other mobile devices were perceived to be a problem in classroom settings, today, they are proving to be more beneficial. There are many apps that have proven to be very valuable in improving student’s learning experience both inside and outside classroom—and ClassDojo tops the list of such apps.

ClassDojo is an app created by Liam Don and Sam Chaudhary to allow students, teachers, and parents communicate and share information, pictures, and school events. Since its inception, the app has been adopted by 90 percent of US K-8 schools and in over 180 countries world-wide. Here are some of the top capabilities of the app:

Positive classroom cultureEncourage school valuesGiving students a VoiceSeamless sharing of moments with familiesVariety of language optionsPrivate messaging capabilities

  • Positive classroom culture: the app allow students to grow by giving them positive feedbacks at a personal and group level
  • Encourage school values: the app can be customized to bring good skills such as the Leader in Me, PBIS, and Three Be’s in classroom setting.
  • Giving students a Voice: students have an opportunity to post some of their favorite photos, videos, and other graphics of their class work to their own class stories.
  • Seamless sharing of moments with families: the app can also allow students to share their photos and videos of their class stories and other school events with their parents without sharing contact details.
  •  Variety of language options: Teachers, students, and parents can translate all the posts from one language to another with just a tap.
  • Private messaging capabilities: students, parents, and teachers can easily share messages privately via the platform without the need to exchange contacts.

Put simply, the app is transforming education globally by helping students, teachers, and parents create implausible classroom settings—all by their own.

Eric Pulier Showcases How Technology Can Be Used to Improve Lives

There’s certainly a lot of impressive talent to be found in the tech sphere. It’s an industry where people tend to shine with impressive results. But sometimes a person becomes notable for how they’re able to use those results to change the world for the better. This is one of the reasons why Eric Pulier often receives so much attention. He’s someone who uses his amazing talents to make the world a better place. He’s made so much of an impact that even presidents have taken note. His bridge to the 21st century was a notable part of Clinton’s 2nd inauguration.

There’s many examples of how he’s been able to accomplish this feat. The inauguration event does serve to highlight one of the most important aspects of career though. One of the most notable aspects of Pulier’s life comes from integration. His bridge to the 21st century showcased how different aspects of the world can come together to create a seamless whole. And in many ways this also describes approach to the world.

Pulier’s love of technology began not as something that was a singular focus, but as one aspect of his overall education. The fact that it began when he was in 4th grade should be given special attention though. Computers weren’t seen as the commonplace item they are today. To learn about computers at that time required special motivation. Even at that young age he went out of his way to expand his view of the world. Technology was a strong part of that. But it was an interest which showed itself as part of his overall curiosity about the world.

This is part of why his academic focus later in life would sit so heavily in literature rather than technology. Technological innovation is obviously an important part of his life. But for Pulier, it’s not the final destination. It’s one tool among many that can help him further his larger vision. A vision which focuses on helping improve the world and the lives of the people in it. For more info about us: https://growthhackers.com/members/ericpulier click here.

This shows itself in a lot of his later ventures. His work with the Xprize showcases his understanding of how to motivate people to be their best. The Painted Turtle shows an example of how his work has directly impacted the lives of children dealing with chronic illness. HIs work with startups has also demonstrated just how important it can be to look to the future. Pulier’s life is one of constant growth and exploration. He’s shown that great things are possible when one looks at the full picture rather than just a small piece of it.

Scott Rocklage is a Healthcare Celebrity

Scott Rocklage may not be super famous like the actors we watch on television but make no mistake he is a celebrity in the healthcare industry. The 5AM Ventures Managing Partner has been heavily involved with the industry on the managing side for more than 30 years. Read more: Scott Racklage | Bloomberg and Scott Racklage | Crunchbase

He has held several leadership positions with different healthcare companies over his storied career. Chairman and CEO of Cubist Pharmaceuticals, President and CEO of Nycomed Salutar, and various R&D positions at Salutar and Catalytica just to name a few.

His skills as a leader has led to FDA approval of three U.S. New Drug Applications for companies he’s involved with. The PhD constantly keeps himself busy. He is Board Chairman of Rennovia, Kinestral, and Cidara.

5AM Ventures was founded in 2002. Rocklage would become a Venture partner a year after its inception and Managing Partner in 2004. The life science-based venture capital firm is still in early stage thus the name 5AM.

A trend that has been sweeping through the healthcare industry as of late is the ability to target specific mutations or genotypes. Individuals like Rocklage are especially excited about this trend as it opens up the door to treat cancer in more unique ways. This trend may be here to stay however since it has contributed to extending and saving lives.

Scott Rocklage possesses a B.S. in Chemistry from the University of California and Berkeley as well as a PhD from MIT. While at the institute of technology he conducted research in the laboratory of Richard R. Schrock, who happens to be a Nobel Peace prize winner.

USHEALTH ADVISORS INSURANCE

USHEALTH ADVISORS

USHEALTH Advisors is a publicizing arm of USHEALTH GROUP that takes into consideration marketing of a collection of adamant fitness attention strategies guaranteed and the insurance offered by the family of USHEALTH groups.

The targeted persons are at this moment the individual American, small business owners and their employees and even self-employed entrepreneurs.

Therefore, for over the past 35yrs, USHEALTH Advisors and USHEALTH group and the related companies have been on the run in serving the different wants of the individual health care. The variety of products have expanded the opportunity to serve individual insurance needs as the health cost rises.

USHEALTH ADVISORS Insurance

USHEALTH Group together with the related companies, by the help of their solely owned subordinate USHEALTH Advisors deals with specified sickness, life, and additional products. Amidst the complicated insurance world, the same USHEALTH advisors having met specific set training goals and certification standards can help the customers through guidance and also assure them of a good purchase involvement. The advisors are in a position to represent the company products after meeting the qualifications

USHEALTH Advisors are committed to giving personal attention which gives them a good appearance and has made them be at the forefront leading to their recognition in the business growth, innovation, and customer care. It has resulted in thousands of individuals and families together with small business owners to turn to USHEALTH Group for insurance coverage needs.

With regards from the BBB reviews of the USHEALTH Advisors, It is evident that the Terms and services of USHEALTH can be rated the best. Without any doubt of fear or favor, It is very much visible that the USHEALTH has offered services that are adorable and any person, Family or Business person is very much content and is ready to introduce any other close person to the same group. In a rate of 0 – 10 having zero to be the poorest performance and ten being the best performance, with much respect and without exaggeration I would rate USHEALTH a 9 star and this I would give, not because it isn’t the best but to give room for improvement https://twitter.com/ushadvisors?lang=en

USHEALTH Advisor’s Information and Advantages

USHEALTH Advisor is an organization headquartered in Dallas, Texas. The identity-acronym for the staff and management at USHEALTH Advisor is HOPE which stands for Helping Other People Every day. The company has been operational in the business industry for fifty-seven years now. Since its establishment, the employees at US Health are its biggest asset. Most of the worker’s salaries are amazing. USHEALTH employees are rewarded with various incentives including wages, salaries, bonuses and hourly-earnings based upon operator’s estimates and reports. USHEALTH Advisor provides different position categories with possible earning rates. For instance, an account manager at the organization is likely to receive a salary summing up to $52,078 annually. On the other hand, insurance agents earn $85,037 per year.

 

A typical Insurance Agent of USHEALTH Advisors earns a salary worth $70,038. The agent’s bonuses and additional compensations usually average to approximately $132,452. Besides equipping its employees with better income, USHEALTH Advisor has many benefits and advantages. The most interesting circumstance of a worker at the company is the ability to perform your roles from home. At USHAELTH Advisors, work from home is recommended for the employees whose indicate a sense of commitment in the duties. Additionally, various agents get performance bonuses on a monthly-basis for a job well done. This extra amount enhances the agency’s revenue increasing them to perform the enterprise’s duties to the optimal.

 

USHEALTH Advisors provide its login details that have experienced six successful tests and rated at 66%. The company’s login feature is agent.usadvisors.com. According to analysis, the page load time at the premium response was 224ms. Later, the web page takes 1.8 seconds to load all the resources at the DOM and render the web page fully operational. This analysis of USHEALTH Advisor’s login credential provides good test results as only 30% of available websites load quicker. In the case of redirects, the browser reached the company’s domain web in three steps. The first redirect was at hhtps://agent.usadvisor.com/. Later, the redirect forwarded to another domain. According to the technological expertise, USHEALTH Advisors login will minimize redirect rates to cub slower web page loading for the user’s access to the organization’s information. https://www.ushealthgroup.com/aboutushg.aspx

Securus Technologies Bringing Smiles on the Faces of Inmates

Many companies have played a pivotal role in the development of the correctional industry over the years. However, one of the companies that have contributed the most to this sector since its inception is Securus Technologies. Over a million inmates use its products and services, and more than three thousand law enforcement agencies are using the criminal justice technology provided by the company. One of the many reasons why Securus Technologies has been dominating the industry is that it has been able to gain the trust of its customers through exceptional customer service. The company hasn’t outsourced its customer service but instead has its customer service department that takes care of all the queries and issues of the customers.

 

Securus Technologies has been playing a vital role in the development of the correctional industry. Some of the products and services offered by Securus were previously thought to be impossible. One of the many reasons why the inmate communication has developed so much in the past few years is because of the contributions of the company. Securus Technologies believe that it is essential for the company to meet the demands of the inmates who are going through tough time inside the jail. Providing them with advanced inmate communication services is what the company feels is its responsibility. Other than the inmate communication, the company also offers investigative technology, government information management system, criminal justice technology, crime prevention technology, and parolee tracking system.

 

As a customer for the past five years and counting, I feel that Securus Technologies has no competition in the correctional industry. The company offers not only the best of technology but also ensures that the customers are getting value for money products and services. I am delighted with the inmate communication services it provides.

 

USHEALTH Advisors; Defining The Path for The Future of Insurance

USHEALTH Advisors, a subsidiary of the prolific USHEALTH Group is tasked with handling the group’s marketing facilities. This includes marketing USHEALTH’s comprehensive portfolio to potential clients seeking various health insurance coverage plans. The insurance packages are optimized for the independent entrepreneur, the average American, and his or her family, the small business owner and his or her throng of employees.

 

 

USHEALTH Advisors has gone above the fray by being able to tailor their portfolio to suit the intended demographic. They have a diverse and competitive insurance portfolio which essentially meets the progressive needs of their targeted client base. The advisors run their operations from the foundation of their mission which is embodied in the acronym HOPE; help other people every day.

 

 

USHEALTH Advisors Insurance

 

America’s trusted choice for health care; USHEALTH Advisors runs its operations through its countrywide agents and various subsidiaries as well. The marketing arm creates strategic and customized marketing packages that appeal to the masses in terms of price and sustainability. They have also heavily invested in ensuring that each of their agents is fully trained and can provide adequate guidance to their large pool of clients.

 

 

USHEALTH Advisors creates a conducive work environment for each agent by ensuring that they have access to 24/7 corporate support. They also came up with an automated self-service platform for each policyholder that signed up through one of their agents. This channel doubles up as a suggestion or comment section for the agents and policyholders as well.

 

 

Countrywide agents are assured of bonus incentives that act as a motivator to gain and retain clients for a certain period of time. Finally, the compensation packages are appealing and essentially, it is possible for any agent to earn a monthly six figure salary if they demonstrate hard work and consistency. USHEALTH Advisors pays their agents commissions weekly or monthly alongside a lucrative annual salary package.

 

 

USHEALTH Business Profile

 

USHEALTH Advisors has its flagship office in Dallas, Texas. You need to gain access to their website, and then the sites’ administrator will generate your login credentials. The firm has over five decades of experience and top notch provision of comprehensive insurance packages to over 15million clients to date. https://www.crunchbase.com/organization/ushealth-advisors#/entity